Project objectives
Sharing across regions information on clinical pathways obtained from common data bases. A data integration open software will be designed, developed, tested, validated and applied to some case studies to interpret clinical pathways of patients with chronic diseases.


Background
Italian administrative databases have a common national data model and collect details on publicly-funded  healthcare delivered to the population by any facility. Overall almost 2 billions records are collected. This national unparalleled asset offers opportunity for innovative generation of information.

Source of funding
Ministry of Health

Leader
National Agency for Regional Health Services (Agenas)

Participants
Ministry of Health, Tuscany Regional Health Agency (ARS Toscana), National Research Council, 5 Italian Regions, Italian College of General Practitioners, University of Milan, Erasmus Medical Center of Rotterdam


Role of the Tuscany Regional Health Agency (ARS Toscana)

• Responsible of the validation study aimed to identify subjects with chronic diseases from Italian administrative databases
• Responsible for design, development and test the software TheMatrix for flexible data integration of Italian administrative data bases
• Support in identification of standards of care for chronic diseases, in dissemination activities, in application of the tools to case studies

Scientific contact in ARS Toscana
Rosa Gini

Duration
3 years

Current state
Ongoing



Publications

• Gini R. A Validation Odyssey: From big data to local intelligence Validity of case-finding algorithms and of measures of quality of care for chronic diseases in Italian Administrative Databases. PhD thesis, October 2016 (in print). Attachments: Subqueries based on ICD9CM codes, Chapter 3 - Supplementary table and Supplementary material

 Documents

• Programma Mattoni del SSN - Progetto MATRICE. Integrazione dei contenuti informativi per la gestione sul territorio di pazienti con patologie complesse o con patologie croniche. Data sheet prepared by the National Agency for Regional health services Agenas (in Italian language)
• Diabete mellito II - Type 2 Diabetes Mellitus, pathology sheet (in Italian language)
• Scompenso cardiaco - Heart failure, pathology sheet (in Italian language)
• Cardiopatia ischemica cronica - Chronic ischemic heart disease, pathology sheet (in Italian language)
• Demenza - Dementia, pathology sheet (in Italian language)
• Ipertensione arteriosa ischemica - Ischemic Arterial Hypertension, pathology sheet (in Italian language)
  

Presentations and posters

• Gini R, Schuemie MJ, Mazzaglia G, Lapi F, et al. Automatic identification of stages of type 2 diabetes, hypertension, ischaemic heart disease and heart failure from Italian General Practioners' electronic medical records: a validation study.
  The abstract of the poster is at page 538 in: Abstracts of the 31st International Conference on Pharmacoepidemiology and Therapeutic Risk Management, August 22-26, 2015, Boston, Massachusetts, USA. Pharmacoepidemiol Drug Saf. Sep 2015;24:1-587.
• Gini R, Schuemie MJ, Pasqua A, Dazzi P, et al. Identifying Chronic Conditions from Data Sources with Incomplete Diagnostic Information: The Case of Italian Administrative Databases.
• The abstract of the poster is at pages 538-539 in: Abstracts of the 31st International Conference on Pharmacoepidemiology and Therapeutic Risk Management, August 22-26, 2015, Boston, Massachusetts, USA. Pharmacoepidemiol Drug Saf. Sep 2015;24:1-587.
• Gini R, Perego R. L'architettura distribuita di MATRICE. Presentazione illustrata al convegno finale del progetto, Rome, May 11, 2015 (in Italian language)
• Validazione di algoritmi per individuare diabete, ipertensione e cardiopatia ischemica dai database amministrativi italiani: lo studio MATRICE - presentazione discussa al XXXVIII Congresso AIE, Naples, November 5-7, 2014 (in Italian language)
• TheMatrix: Il software - October 20-23, 2014 (in Italian language)
• Studio del progetto MATRICE - October 17, 2014 (in Italian language)
• Validare definizioni di caso di patologia cronica da database ammministrativi italiani: risultati del progetto MATRICE - July 29, 2014 (in Italian language)
• Validating case definitions of chronic diseases in Italian regional health service databases: results from the MATRICE Project presentazione discussa al Workshop Doing research in healthcare with administrative databases - June 30, 2014
• Comparison among EU-ADR, OMOP, Mini-Sentinel and MATRICE strategies for data extraction and management (agosto 2013) selected for an oral presentation at  29th International Conference on Farmacoepidemiology and Management of Therapeutic Risk
• The Matrix software allows the construction of a virtual database, based on data coming from local Italian administrative databases, through an ad-hoc scripting language
• Frameworks for Data Extraction and Management from Electronic Healthcare Databases for Multi-Center Epidemiologic Studies: a Comparison among EU-ADR, MATRICE, and OMOP Strategies. Workshop held on Nov 22, 2012 at the Department of Medical Statistics at Erasmus University in Rotterdam
• Quando i registri nascono dall'uso integrato dei sistemi informativi sanitari: quali strumenti per garantire qualità? Spring Congress of the Italian Association of Epidemiology. Misurare la salute. Rome, May 28-29, 2012 (in Italian language)
• Il progetto MATTONI/MATRICE dell'Agenas. Workshop held by Istituto superiore di sanità “La Genesi dei Sistemi”. Florence, May 23‐24, 2012 (in Italian language)

Scientific articles

• Gini R, Schuemie MJ, Francesconi P, Lapi F, Cricelli I, et al. (2014) Can Italian healthcare administrative databases be used to compare regions with respect to compliance with standards of care for chronic diseases? PLoS ONE 9(5): e95419. doi:10.1371/journal.pone.0095419

 

Events

• Assistenza primaria: monitoraggio della qualità e valutazione d'impatto nei progetti Agenas MATRICE - MEDINA - LUNA. Convegno finale del progetto, organizzato da AGENAS in data 11 maggio 2015
• Workshop Doing research in healthcare with administrative databases - 30 giugno 2014
  

To take a deeper dive into the topic

• watch our videonews e videointervista sul progetto MATRICE (in Italian language)
• Read the articles on Matrice published in Il Sole 24 Ore Sanità (in Italian language)
• Read our news Dati e politiche sanitarie, l'abstract dell'ARS alla conferenza internazionale di farmacoepidemiologia (in Italian language)
• Read our news on the presentation of TheMatrix software Dati sanitari correnti in epidemiologia, l'ARS interviene al corso ISS (in Italian language)