Antiepileptic drug prescribing before, during and after pregnancy: a study in seven European regions

pubblicazioni ars 2015Autori: Charlton R, Garne E, Wang H, Klungsøyr K, Jordan S, Neville A, Pierini A, Hansen A, Engeland A, Gini R, Thayer D, Bos J, Puccini A, Nybo Andersen AM, Dolk H, de Jong-van den Berg L.

Rivista:  Pharmacoepidemiol Drug Saf. 2015 Nov;24(11):1144-54.

PURPOSE: The aim of this study was to explore antiepileptic drug (AED) prescribing before, during and after pregnancy as recorded in seven population-based electronic healthcare databases.

METHODS: Databases in Denmark, Norway, the Netherlands, Italy (Emilia Romagna/Tuscany), Wales and the Clinical Practice Research Datalink, representing the rest of the UK, were accessed for the study. Women with a pregnancy starting and ending between 2004 and 2010, which ended in a delivery, were identified. AED prescriptions issued (UK) or dispensed (non-UK) at any time during pregnancy and the 6 months before and after pregnancy were identified in each of the databases. AED prescribing patterns were analysed, and the choice of AEDs and co-prescribing of folic acid were evaluated.

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